Posted on 
Aug 1

Bioprocess Engineer

As a Bioprocess engineer, you will be part of a collaborative R&D team developing and optimising bioprocesses for the transformation of plastic into chemicals and will be charged with leading the bioprocess engineering efforts. The prime area of responsibility will be to develop improved methods for recombinant protein production. This includes the optimisation and process scale up of the entire enzyme production process, including downstream aspects, from lab to industrial scale as well as driving down cost of production. You will work closely with the strain development team on microbial engineering strategies. In addition, you will work on developing and implementing strategies for testing the enzyme to break down the plastics in novel bioreactors at increasingly larger bench scales to understand enzyme performance. The position is part hands-on laboratory work but also includes organisation tasks and supervision of team members.

Key responsibilities and tasks:
- Evaluate strains in bioreactors, including analysis of metabolic, physiological, and performance parameters
- Medium and feed optimisation, enzyme expression and a variety of physiological assays to provide high-quality material for high throughput analysis of protein variants.
- Design and optimise bioprocesses to improve strain performance (titers, rates, yields, etc.)
- Development of downstream processes
- Build-out of new experimental facilities at laboratory scale to enable robust testing of reaction operations
- Develop plan for scale-up of bioprocesses from lab scale to industrial scale
- Prepare technical reports, SOPs, and presentations
- Find and coordinate with appropriate collaboration partners and suppliers to support above activities

We would like to hear from you if you have:
- Msc or PhD in bioprocess engineering or similar field
- Extensive hands-on experience with fermentation science, microbiology and protein production, ideally acquired through post-doctoral experience or equivalent level (>5 years) in industry
- Strong expertise with different bioprocesses, including batch, fed-batch and continuous processes
- Experience optimising microbial growth and protein expression in bioreactors
- A good understanding of microbial physiology and its measurements using modern instrumentation
- Experience in scaling up enzymatic and whole-cell fermentations
- Experience in optimisation of downstream processes
- Excellent communication skills.
- Experience working in multidisciplinary teams

Cherries on the cake would be:
- Previous work in industry, especially in a high-growth startup
- An interest in and previous experience with high-throughput lab automation
- Knowledge of and experience with modern methods of synthetic and molecular biology

Description

As a Bioprocess engineer, you will be part of a collaborative R&D team developing and optimising bioprocesses for the transformation of plastic into chemicals and will be charged with leading the bioprocess engineering efforts. The prime area of responsibility will be to develop improved methods for recombinant protein production. This includes the optimisation and process scale up of the entire enzyme production process, including downstream aspects, from lab to industrial scale as well as driving down cost of production. You will work closely with the strain development team on microbial engineering strategies. In addition, you will work on developing and implementing strategies for testing the enzyme to break down the plastics in novel bioreactors at increasingly larger bench scales to understand enzyme performance. The position is part hands-on laboratory work but also includes organisation tasks and supervision of team members.

Key responsibilities and tasks:
- Evaluate strains in bioreactors, including analysis of metabolic, physiological, and performance parameters
- Medium and feed optimisation, enzyme expression and a variety of physiological assays to provide high-quality material for high throughput analysis of protein variants.
- Design and optimise bioprocesses to improve strain performance (titers, rates, yields, etc.)
- Development of downstream processes
- Build-out of new experimental facilities at laboratory scale to enable robust testing of reaction operations
- Develop plan for scale-up of bioprocesses from lab scale to industrial scale
- Prepare technical reports, SOPs, and presentations
- Find and coordinate with appropriate collaboration partners and suppliers to support above activities

We would like to hear from you if you have:
- Msc or PhD in bioprocess engineering or similar field
- Extensive hands-on experience with fermentation science, microbiology and protein production, ideally acquired through post-doctoral experience or equivalent level (>5 years) in industry
- Strong expertise with different bioprocesses, including batch, fed-batch and continuous processes
- Experience optimising microbial growth and protein expression in bioreactors
- A good understanding of microbial physiology and its measurements using modern instrumentation
- Experience in scaling up enzymatic and whole-cell fermentations
- Experience in optimisation of downstream processes
- Excellent communication skills.
- Experience working in multidisciplinary teams

Cherries on the cake would be:
- Previous work in industry, especially in a high-growth startup
- An interest in and previous experience with high-throughput lab automation
- Knowledge of and experience with modern methods of synthetic and molecular biology

Responsibilities

Requirements

Offer

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